Search | Engineering

Subscribe Submit

Home Journals Focus Achievement Fronts About Us 中文版

Resource Type

Journal Article 125

Conference Videos 4

Year

2023 13

2022 14

2021 13

2020 9

2019 7

2018 12

2017 8

2016 5

2015 3

2014 7

2013 11

2012 3

2011 3

2010 2

2009 1

2008 5

2007 4

2001 2

open ︾

Keywords

diabetes 13

type 2 diabetes 4

type 2 diabetes mellitus 4

CO₂ capture 3

COVID-19 3

Diabetes 3

Cancer 2

Cardiovascular disease 2

Post-exascale 2

Treg 2

abortion 2

inflammation 2

prognosis 2

C14H8orf33 gene 1

N-glycosylation 1

Pm21 1

Pm40 1

AMPK 1

Accelerator 1

open ︾

Search scope:

排序： Display mode:

Alterations in the Gut Microbiome in Liver Recipients with Post-transplant Diabetes Mellitus Article

Qi Ling, Yuqiu Han, Yue Ma, Xiaosen Wang, Zheng Zhu, Jingyu Wang, Jiaying Cao, Lin Xiaohan, Jun Wang, Baohong Wang

Engineering 2023, Volume 31, Issue 12, Pages 98-111 doi: 10.1016/j.eng.2023.09.006

Abstract:

Post-transplant diabetes mellitus (PTDM) increases the risk of graft failure and death in liver transplantrecipient cohort with or without PTDM and deciphered the potential relationship among IM, TAC dosage, and diabetesBy comparing with both non-PTDM and classical type 2 diabetes mellitus (T2DM), we identified microbial

Keywords： Post-transplant diabetes mellitus Tacrolimus Metagenomics Metabolomics

HTML PDF Collect

Role of Intrahepatic Regional Immunity in Post-Transplant Cancer Recurrence Review

Jiang Liu,Chung Mau Lo,Kwan Man

Engineering 2022, Volume 10, Issue 3, Pages 57-64 doi: 10.1016/j.eng.2021.11.012

Abstract:

Hepatic malignancy is a major indication for liver transplantation; however, post-transplant cancerPre-transplant tumor biology, staging, and post-transplant immunosuppression regimens have been elucidatedHowever, the role of regional immunity in post-transplant cancer recurrence is not comprehensively understoodregional immunity will provide novel precise diagnostic, therapeutic, and prognostic strategies for post-transplant

Keywords： Liver transplantation Liver cancer Recurrence Immunology

HTML PDF Collect

Correlation between serum miR-154-5p and urinary albumin excretion rates in patients with type 2 diabetesmellitus: a cross-sectional cohort study

Huiwen Ren, Can Wu, Ying Shao, Shuang Liu, Yang Zhou, Qiuyue Wang

Frontiers of Medicine 2020, Volume 14, Issue 5, Pages 642-650 doi: 10.1007/s11684-019-0719-3

Abstract: correlation between serum miR-154-5p and urinary albumin to creatinine ratio (UACR) in patients with type 2 diabetesmellitus (T2DM) and the association with biomarkers of inflammation and fibrosis in diabetic kidney

Keywords： type 2 diabetes mellitus diabetic kidney disease miR-154-5p urinary albumin to creatinine ratio

HTML PDF Collect

Association of periodontal disease with glycemic control in patients with type 2 diabetes in Indian population

Palka Kaur Khanuja,Satish Chander Narula,Rajesh Rajput,Rajinder Kumar Sharma,Shikha Tewari

Frontiers of Medicine 2017, Volume 11, Issue 1, Pages 110-119 doi: 10.1007/s11684-016-0484-5

Abstract: A total of 207 patients with type 2 diabetes and chronic periodontitis (CP) were divided according toanalyses were carried out for glycated hemoglobin (HbA_1c), fasting plasma glucose (FPG), 2 h postAfter controlling for age, gender, body mass index (BMI), socioeconomic status (SES), family history of diabetesand periodontitis, duration of diabetes, the mean PISA in mm², PPD 4--6 mm (%) and PPD&ge

Keywords： type 2 diabetes mellitus hemoglobin A glycated chronic periodontitis

HTML PDF Collect

Adiponectin: mechanisms and new therapeutic approaches for restoring diabetic heart sensitivity to ischemic post-conditioning

Tingting Wang, Shanglong Yao, Zhengyuan Xia, Michael G. Irwin

Frontiers of Medicine 2013, Volume 7, Issue 3, Pages 301-305 doi: 10.1007/s11684-013-0283-1

Abstract: Ischemic post-conditioning (IPostC) has emerged as a promising method for myocardial protection againstPlasma levels of APN are decreased in obese subjects and in patients with type 2 diabetes.highlighted the potential effectiveness and mechanism of APN in restoring IPostC cardioprotection in diabetesof novel and optimal therapies to enhance cardioprotection in patients with severe diseases such as diabetes

Keywords： adiponectin ischemic post-conditioning ischemia reperfusion injury diabetes

HTML PDF Collect

Cytokines and inflammation in adipogenesis: an updated review

Ning Jiang, Yao Li, Ting Shu, Jing Wang

Frontiers of Medicine 2019, Volume 13, Issue 3, Pages 314-329 doi: 10.1007/s11684-018-0625-0

Abstract: The biological relevance of cytokines is known for more than 20 years. Evidence suggests that adipogenesis is one of the biological events involved in the regulation of cytokines, and pro-inflammatory cytokines (e.g., TNF and IL-1 ) inhibit adipogenesis through various pathways. This inhibitory effect can constrain the hyperplastic expandability of adipose tissues. Meanwhile, chronic low-grade inflammation is commonly observed in obese populations. In some individuals, the impaired ability of adipose tissues to recruit new adipocytes to adipose depots during overnutrition results in adipocyte hypertrophy, ectopic lipid accumulation, and insulin resistance. Intervention studies showed that pro-inflammatory cytokine antagonists improve metabolism in patients with metabolic syndrome. This review focuses on the cytokines currently known to regulate adipogenesis under physiological and pathophysiological circumstances. Recent studies on how inhibited adipogenesis leads to metabolic disorders were summarized. Although the interplay of cytokines and lipid metabolism is yet incompletely understood, cytokines represent a class of potential therapeutic targets in the treatment of metabolic disorders.

Keywords： cytokines inflammation adipogenesis type 2 diabetes mellitus metabolic disorder

HTML PDF Collect

Impact of diabetes and its treatments on skeletal diseases

Wenbo Yan, Xin Li

Frontiers of Medicine 2013, Volume 7, Issue 1, Pages 81-90 doi: 10.1007/s11684-013-0243-9

Abstract:

Diabetes mellitus is an enormous menace to public health globally.Both type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM) are associated with an increasedHow diabetes accelerates the deterioration of cartilage remains largely unknown.influence skeletal tissues is in great need in view of the growing and aging population of patients with diabetesmellitus.

Keywords： diabetes bone osteoporosis osteoarthritis

HTML PDF Collect

Difference between 2 h and 3 h 75 g glucose tolerance test in the diagnosis of gestational diabetes mellitus

Xue-Lian GAO, Yu-Mei WEI, Hui-Xia YANG, Xian-Ming XU, Ling FAN, Jing HE, Ning LIU, San-Cun ZHAO, Ya-Li HU, Zi YANG, Yun-Ping ZHANG, Xing-Hui LIU, Xu CHEN, Jian-Ping ZHANG, Wen-Li GOU, Mei XIAO, Hai-Rong WU, Mei-Hua ZHANG

Frontiers of Medicine 2010, Volume 4, Issue 3, Pages 303-307 doi: 10.1007/s11684-010-0090-x

Abstract: alternative to the 3 h OGTT was investigated based on data from a national survey on pregnancy-associated diabetesAccording to American Diabetes Association (ADA) gestational diabetes mellitus (GDM) diagnostic criteria

Keywords： diabetes gestational oral glucose tolerance test

HTML PDF Collect

Type 2 diabetic patients with non-alcoholic fatty liver disease exhibit significant haemorheological abnormalities

Hui Dong, Fu’er Lu, Nan Wang, Xin Zou, Jingjing Rao

Frontiers of Medicine 2011, Volume 5, Issue 3, Pages 288-293 doi: 10.1007/s11684-011-0127-9

Abstract: Haemorheological abnormalities have been described in diabetes mellitus, as well as in non-alcoholiccorrelation between haemorheological parameters and intrahepatic lipid content (IHLC) in patients with type 2 diabetesIn summary, haemorheological disorders are linked to non-alcoholic fatty liver in type 2 diabetes.

Keywords： diabetes mellitus type 2 haemorheology non-alcoholic fatty liver disease

HTML PDF Collect

evaluation of renal function using diffusion weighted imaging and diffusion tensor imaging in type 2 diabetics with normoalbuminuria versus microalbuminuria

Xiaoyan Chen,Wenxia Xiao,Xinchun Li,Jianxun He,Xiaochun Huang,Yuyu Tan

Frontiers of Medicine 2014, Volume 8, Issue 4, Pages 471-476 doi: 10.1007/s11684-014-0365-8

Abstract:

This work aims to estimate the value of diffusion weighted imaging (DWI) and diffusion tensor imaging (DTI) in detecting early-stage kidney injury in type 2 diabetic patients with normoalbuminuria (NAU) versus microalbuminuria (MAU) prospectively. A total of 30 T2DM patients with normal kidney function were recruited and assigned to the NAU group (n = 14) or MAU group (n= 16) according to 8 h overnight urinary albuminuria excretion rate (AER) results. A contemporary cohort of health check-up recipients were included as controls (n = 12). DWI and DTI scans were performed on bilateral kidney using SE single-shot EPI, and apparent diffusion coefficient (ADC) and fractional anisotropy (FA) of the renal parenchyma was determined from ADC and FA maps of the three groups. ADC and FA values were compared among the three groups. According to DWI with a b value of 400 s/mm², the MAU and NAU groups showed significantly lowered mean ADC values compared with the healthy controls (P<0.01). The mean ADC in the MAU group [(2.22±0.07)×10^–3 mm²/s] was slightly lower than that of the NAU group [(2.31±0.22)×10^–3 mm²/s], but this difference was not statistically significant (P>0.05). The FA value in the MAU group was higher than that in the control group (0.45±0.07 vs. 0.39±0.03, P = 0.004) but did not differ from that in the NAU group (0.42±0.03) (P>0.05). ADC and FA values may be more sensitive than urine AER in reflecting early-stage kidney injury and, hence, may facilitate earlier detection and quantitative evaluation of kidney injury in T2DM patients. Combined evaluation of ADC and FA values may provide a better quantitative approach for identifying diabetic nephropathy at early disease stages.

Keywords： type 2 diabetes mellitus microalbuminuria diffusion weighted imaging diffusion tensor imaging early-stage

HTML PDF Collect

New practice in semaglutide on type-2 diabetes and obesity: clinical evidence and expectation

Frontiers of Medicine 2022, Volume 16, Issue 1, Pages 17-24 doi: 10.1007/s11684-021-0873-2

Abstract: Obesity is an important risk factor of type 2 diabetes (T2D), which has become an important factor threatening

Keywords： semaglutide type 2 diabetes obesity

HTML PDF Collect

Xiao Ke Qing improves glycometabolism and ameliorates insulin resistance by regulating the PI3K/Akt pathway in KKAy mice

Xiaoqing Li, Xinxin Li, Genbei Wang, Yan Xu, Yuanyuan Wang, Ruijia Hao, Xiaohui Ma

Frontiers of Medicine 2018, Volume 12, Issue 6, Pages 688-696 doi: 10.1007/s11684-018-0662-8

Abstract:

Xiao Ke Qing (XKQ) granule has been clinically used to treat type 2 diabetes mellitus (T2DM) for 10This study aims to investigate XKQ mechanisms on diabetes and diabetic liver disease by using the KKAy

Keywords： XKQ type 2 diabetes mellitus KKAy mice PI3K/Akt pathway diabetic liver disease

HTML PDF Collect

Prognostic value of fasting glucose on the risk of heart failure and left ventricular systolic dysfunction in non-diabetic patients with ST-segment elevation myocardial infarction

Hui Wang, Yang Zhang, Zhujun Shen, Ligang Fang, Zhenyu Liu, Shuyang Zhang

Frontiers of Medicine 2021, Volume 15, Issue 1, Pages 70-78 doi: 10.1007/s11684-020-0749-x

Abstract: Recent studies have shown that acute blood glucose elevation in patients with ST-segment elevation myocardial infarction (STEMI) suggests a poor prognosis. To investigate the effect of fasting blood glucose (FBG) on the risk of heart failure (HF) and left ventricular systolic dysfunction (LVSD) in non-diabetic patients undergoing primary percutaneous coronary intervention (PCI) for acute STEMI, we retrospectively recruited consecutive non-diabetic patients who underwent primary PCI for STEMI in our hospital from February 2003 to March 2015. The patients were divided into two groups according to the FBG level. A total of 623 patients were recruited with an age of 61.3±12.9 years, of whom 514 (82.5%) were male. The HF risk (odds ratio 3.401, 95% confidence interval (CI) 2.144–5.395, <0.001) was significantly increased in patients with elevated FBG than those with normal FBG. Elevated FBG was also independently related to LVSD (β 1.513, 95%CI 1.282–1.785, <0.001) in a multiple logistics regression analysis. In conclusion, elevated FBG was independently associated with 30-day HF and LVSD risk in non-diabetic patients undergoing primary PCI for STEMI.

Keywords： myocardial infarction percutaneous coronary intervention diabetes mellitus fasting glucose heart failure

HTML PDF Collect

Traditional Chinese Medicine-Based Subtyping of Early-Stage Type 2 Diabetes Using Plasma Metabolomics Article

Min He, Mengmeng Sun, Slavik Koval, Roeland Van Wijk, Thomas Hankemeier, Jan Van der Greef, Eduard P.A. Van Wijk, Mei Wang

Engineering 2019, Volume 5, Issue 5, Pages 916-923 doi: 10.1016/j.eng.2019.03.011

Abstract:

The prevalence of type 2 diabetes mellitus (T2DM) is increasing rapidly worldwide.

Keywords： Type 2 diabetes mellitus Plasma metabolites Disease subtypes Ultra-weak photon emission Correlation

HTML PDF Collect

Early-onset diabetes: an epidemic in China

Jiemin Pan, Weiping Jia

Frontiers of Medicine 2018, Volume 12, Issue 6, Pages 624-633 doi: 10.1007/s11684-018-0669-1

Abstract:

Although type 2 diabetes is a disease often associated with aging, the global prevalence of early-onsetdiabetes has been increasing due to man’s sedentary lifestyle, low-physical activity, obesity, and somevascular complications than those with late-onset diabetes.Individuals with early-onset diabetes are usually unwilling to visit hospital and have more confidencein their health, which results in poor glycemic control and the delayed detection of diabetes-related

Keywords： diabetes early-onset diabetes complications

HTML PDF Collect

Title Author Date Type Operation

Alterations in the Gut Microbiome in Liver Recipients with Post-transplant Diabetes Mellitus

Qi Ling, Yuqiu Han, Yue Ma, Xiaosen Wang, Zheng Zhu, Jingyu Wang, Jiaying Cao, Lin Xiaohan, Jun Wang, Baohong Wang

Journal Article

Role of Intrahepatic Regional Immunity in Post-Transplant Cancer Recurrence

Jiang Liu,Chung Mau Lo,Kwan Man

Journal Article

Correlation between serum miR-154-5p and urinary albumin excretion rates in patients with type 2 diabetesmellitus: a cross-sectional cohort study

Huiwen Ren, Can Wu, Ying Shao, Shuang Liu, Yang Zhou, Qiuyue Wang

Journal Article

Association of periodontal disease with glycemic control in patients with type 2 diabetes in Indian population

Palka Kaur Khanuja,Satish Chander Narula,Rajesh Rajput,Rajinder Kumar Sharma,Shikha Tewari

Journal Article

Adiponectin: mechanisms and new therapeutic approaches for restoring diabetic heart sensitivity to ischemic post-conditioning

Tingting Wang, Shanglong Yao, Zhengyuan Xia, Michael G. Irwin

Journal Article

Cytokines and inflammation in adipogenesis: an updated review

Ning Jiang, Yao Li, Ting Shu, Jing Wang

Journal Article

Impact of diabetes and its treatments on skeletal diseases

Wenbo Yan, Xin Li

Journal Article

Difference between 2 h and 3 h 75 g glucose tolerance test in the diagnosis of gestational diabetes mellitus

Journal Article

Type 2 diabetic patients with non-alcoholic fatty liver disease exhibit significant haemorheological abnormalities

Hui Dong, Fu’er Lu, Nan Wang, Xin Zou, Jingjing Rao

Journal Article

evaluation of renal function using diffusion weighted imaging and diffusion tensor imaging in type 2 diabetics with normoalbuminuria versus microalbuminuria

Xiaoyan Chen,Wenxia Xiao,Xinchun Li,Jianxun He,Xiaochun Huang,Yuyu Tan

Journal Article

New practice in semaglutide on type-2 diabetes and obesity: clinical evidence and expectation

Journal Article

Xiao Ke Qing improves glycometabolism and ameliorates insulin resistance by regulating the PI3K/Akt pathway in KKAy mice

Xiaoqing Li, Xinxin Li, Genbei Wang, Yan Xu, Yuanyuan Wang, Ruijia Hao, Xiaohui Ma

Journal Article

Prognostic value of fasting glucose on the risk of heart failure and left ventricular systolic dysfunction in non-diabetic patients with ST-segment elevation myocardial infarction

Hui Wang, Yang Zhang, Zhujun Shen, Ligang Fang, Zhenyu Liu, Shuyang Zhang

Journal Article

Traditional Chinese Medicine-Based Subtyping of Early-Stage Type 2 Diabetes Using Plasma Metabolomics

Min He, Mengmeng Sun, Slavik Koval, Roeland Van Wijk, Thomas Hankemeier, Jan Van der Greef, Eduard P.A. Van Wijk, Mei Wang

Journal Article

Early-onset diabetes: an epidemic in China

Jiemin Pan, Weiping Jia

Journal Article